Teaching Responsibility
LJMU Schools involved in Delivery:
Pharmacy & Biomolecular Sciences
Learning Methods
Lecture
Practical
Workshop
Module Offerings
7127PHASCI-JAN-CTY
Aims
This module aims to cover the R&D aspects of natural products ‘from field to bedside’.
The learning activities will:
(1) Integrate and apply the analytical and phytochemical knowledge acquired in modules 7224PHASCI and 7128PHASCI modules to natural products/drug discovery;
(2) Provide the candidates with further knowledge in preparative chromatography and other isolation methods;
(3) Integrate and apply the chemical knowledge acquired in module 7124PHASCI and 7128PHASCI towards mastery in synthetic and semisynthetic methods applied to natural products;
(4) Provide the candidates with advanced knowledge on strategies to discover new natural products with therapeutic and functional uses.
Learning Outcomes
1.
Independently acquire advanced chemical knowledge and apply specialised methods necessary for the bioprospection, field extraction, and industrial purification of natural products.
2.
Independently acquire, critically evaluate and apply advanced synthetic knowledge to modify the physicochemical properties of natural products.
3.
Demonstrate the necessary skills to plan, perform, report and interpret the results of laboratory experiments, and case studies on the bioprospection, field extraction, chemical modification and industrial purification of natural products
Module Content
Outline Syllabus:Isolation methods (Preparative Chromatography)
Bioguided Isolation Methods
Chemical Libraries-High Throughput Screening
Green Chemistry
Microorganisms and semisynthesis
Academic vs. industrial approaches
Endophytic fungi
Module Overview:
This module covers the systematic approach in drug discovery from natural sources, from the rain forest to the deep oceans and how we sustainably scale up their obtention in full adherence to the biodiversity conventions.
This module covers the systematic approach in drug discovery from natural sources, from the rain forest to the deep oceans and how we sustainably scale up their obtention in full adherence to the biodiversity conventions.
Additional Information:This module takes the very same name of the programme because it integrates all the previous content of the course into a linear and coherent narrative.