Teaching Responsibility
LJMU Schools involved in Delivery:
Pharmacy & Biomolecular Sciences
Learning Methods
Lecture
Practical
Workshop
Module Offerings
5105BCBMOL-JAN-CTY
Aims
To provide a detailed understanding of the molecular mechanisms that are applicable to human disease states, development, genetic engineering, high-throughput technologies, and to introduce and develop bioinformatics practical skills.
Learning Outcomes
1.
Discuss the mechanisms of DNA damage and repair and their contribution to human genetic disease.
2.
Review the principles of the genetic control of development.
3.
Demonstrate an understanding of genetic engineering.
4.
Apply knowledge of the principles, challenges, and applications for Next Generation Sequencing.
Module Content
Outline Syllabus:DNA damage and repair and its impact in human disease states (using a range of biochemical examples which may include: Huntington’s, Fragile -X, Xeroderma pigmentosum, etc.).
Translational control and gene silencing (introduce NMD, microRNA and RNAi).
Developmental biology and genetic programs (basic embryology and genetics).
Introduction to genetic engineering.
Experimental considerations for NGS experiments (feasibility, reproducibility, bias, error and limitations).
Introduction to bioinformatics/omics – (genomics, epigenome, transcriptome, microbiome, and proteomics) and next generation sequencing technologies, GWAS and gene knock-outs/ins.
Introduction to cancer genetics.
Module Overview:
This module provides you with a detailed understanding of the molecular mechanisms that are applicable to human disease states, development and genetic engineering. The module will empower you to demonstrate a critical understanding of genomic integrity and human disease. Transcriptional control, developmental biology, genetic engineering and bioinformatics will be introduced. You will encounter experimental methods for the investigation of the relevant areas of biochemistry and molecular biology using data from high-throughput techniques.
This module provides you with a detailed understanding of the molecular mechanisms that are applicable to human disease states, development and genetic engineering. The module will empower you to demonstrate a critical understanding of genomic integrity and human disease. Transcriptional control, developmental biology, genetic engineering and bioinformatics will be introduced. You will encounter experimental methods for the investigation of the relevant areas of biochemistry and molecular biology using data from high-throughput techniques.
Additional Information:This module will empower students to demonstrate a critical understanding of genomic integrity and human disease. Transcriptional control, developmental biology, genetic engineering and bioinformatics will be introduced. Students will encounter experimental methods for the investigation of the relevant areas of biochemistry and molecular biology using data from high-throughput techniques.