Teaching Responsibility
LJMU Schools involved in Delivery:
Pharmacy & Biomolecular Sciences
Learning Methods
Lecture
Practical
Workshop
Module Offerings
7128PHASCI-SEP-CTY
Aims
This module aims to cover the phytochemical and medicinal chemistry (synthesis) aspects of natural products.
The theoretical Lectures will offer an overview of the major:
(1) Biosynthesis pathways (Shikimate, Mevalonic and amino acid) of natural products (alkaloids, phenolics, terpenes, glycosides and essential oils);
(2) Fundamentals of organic synthesis;
(3) Use of online tools to explore the physicochemical characteristics of phytochemicals.
Learning Outcomes
1.
Demonstrate a thorough knowledge of the biosynthesis, structure and physico-chemical properties of natural products.
2.
Demonstrate a thorough knowledge and practical understanding of how to apply organic chemistry to the semi/synthesis of natural products as well as selected online tools to support organic synthesis design.
3.
Locate, critically evaluate, critically assess and make appropriate use of information from scientific literature and relevant electronic resources on phytochemistry and organic synthesis of natural products.
4.
Demonstrate the necessary skills to plan, perform, report and interpret the results of laboratory experiments and analyses on the chemistry of natural products.
Module Content
Outline Syllabus:1. Plant Metabolism and Enzymes
2. Shikimate Pathway
3. Amino acid Pathways
4. Mevalonic acid Pathway
5. Essential oils
6. Glycosides
7. Historical aspects of Natural Products Chemistry
8. Fundamentals of organic synthesis
9. Online tools and Databases for the study of natural products
Module Overview:
This module covers the main classes of natural products, their chemical and physical behaviour and total/semi-synthesis.
This module covers the main classes of natural products, their chemical and physical behaviour and total/semi-synthesis.
Additional Information:This module will require previous undergraduate and/or postgraduate knowledge in organic chemistry.