Teaching Responsibility
LJMU Schools involved in Delivery:
Pharmacy & Biomolecular Sciences
Learning Methods
Lecture
Practical
Workshop
Module Offerings
7124PHASCI-SEP-CTY
Aims
The course aims to extend students' comprehension and experience in the application of analytical methods for the isolation and identification of lead compounds from a complex mixture of natural products. This will involve the application of advanced chromatography, spectroscopy and spectrometry.
Learning Outcomes
1.
Independently acquire advanced chemical knowledge and apply specialised methods necessary for the extraction, purification and identification of natural products.
2.
Independently acquire advanced chemical knowledge and apply specialised methods necessary for the qualitative and quantitative instrumental analysis of natural products.
3.
Safely solve -alone or as part of a team- multidisciplinary challenges in the field of analysis of natural products even in the absence of complete information.
4.
Ethically source, systematically locate, critically evaluate, objectively assess, and make appropriate use of information from scientific literature and relevant electronic resources in the field of analysis of natural products.
5.
Demonstrate the necessary skills to plan, perform, report and interpret the results of laboratory experiments and analyses applied to natural products.
Module Content
Outline Syllabus:Techniques used for the extraction of natural products, chromatographic techniques for the isolation and purification of compounds and spectroscopic techniques for the identification of compounds.
Extraction: Liquid extraction, fractional distillation
Chromatography: Flash Chromatography, Column Chromatography, TLC, Analytical and preparative HPLC, GC, GC-MS, LC-MS.
Spectroscopy/Spectrometry/Other: UV, IR, NMR (1D and 2D) spectroscopy, mass spectrometry and X-ray crystallography.
Module Overview:
This module covers: techniques used for the extraction (cold extraction, Soxhlet extraction and fractional distillation) of natural products, chromatographic techniques (Flash Chromatography, Column Chromatography, TLC, Analytical and preparative HPLC, GC, GC-MS, LC-MS) for the isolation and purification of compounds and spectroscopic techniques (UV, IR, 1D & 2D NMR spectroscopy, mass spectrometry and X-ray crystallography) for the identification of compounds.
This module covers: techniques used for the extraction (cold extraction, Soxhlet extraction and fractional distillation) of natural products, chromatographic techniques (Flash Chromatography, Column Chromatography, TLC, Analytical and preparative HPLC, GC, GC-MS, LC-MS) for the isolation and purification of compounds and spectroscopic techniques (UV, IR, 1D & 2D NMR spectroscopy, mass spectrometry and X-ray crystallography) for the identification of compounds.
Additional Information:This module builds on fundamental analytical chemistry learned by the candidate during undergraduate and/or postgraduate science, chemistry, healthcare and/or pharmaceutical science degree courses.