Teaching Responsibility

LJMU Schools involved in Delivery:

Pharmacy & Biomolecular Sciences

Learning Methods

Lecture

Practical

Workshop

Module Offerings

7122PHASCI-JAN-CTY

Aims

To develop an integrated understanding of the principles underpinning drug discovery process and of the approaches and rationale of drug optimisation.

Learning Outcomes

1.
Display a systematic understanding of the processes and technologies employed in the discovery and the selection of hits and leads.
2.
Critically evaluate the principles and rationale underpinning lead optimisation.
3.
Synthesise and communicate the impact of experimental findings on the life and fate of a drug candidate.
4.
Integrate and communicate the approaches for drug candidate selection in the context of successful drug development cases.

Module Content

Outline Syllabus:Drug discovery process (including target identification, hit/lead identification, hit-to-lead development step). Compound screening (including experimental and virtual techniques and considering compounds with synthetic and natural sources). Drug design principles (Physical properties, structure-activity relationship). Computer-aided Drug Design. Chemoinformatics including QSAR. Lead optimisation (including synthetic strategies, computational techniques). The discovery of biopharmaceutical drugs Successful drug design case studies (examples could include, but are not limited to, antimicrobials and opioids).
Module Overview:
This module aims to enable you to develop an integrated understanding of the principles underpinning drug discovery process and the approaches and rationale of drug optimisation.
Additional Information:Practical sessions will involve the synthesis of a library of antimicrobial drugs, their testing and the elaboration of structure activity relationships. Exam will assess students understanding of the principles through data interpretation/problem solving questions

Assessments

Centralised Exam

Report