Teaching Responsibility
LJMU Schools involved in Delivery:
Pharmacy & Biomolecular Sciences
Learning Methods
Lecture
Practical
Tutorial
Workshop
Module Offerings
7102BSBMOL-SEP-CTY
Aims
To provide an overview of the roles and investigations of genes and disease.
Learning Outcomes
1.
Demonstrate a reflective understanding of the genetic basis of disease and its investigation.
2.
Apply principles of interpretation to genetic data.
3.
Critically evaluate the literature on genetic disease and research techniques.
Module Content
Outline Syllabus:Lectures:
The module provides a critical appreciation of the human genome, its regulation, functional significance of gene mutations and current approaches of identification of human genetic disorders. Topics covered include:
The human genome, epigenetics, genomic medicine, high throughput genomic techniques, bioinformatics, inborn errors of metabolism, molecular medicine, stem cells, molecular basis of host-pathogen interaction, immunogenetics and disease.
Workshops:
Gene mapping: pedigree analysis and gene mapping using recombination frequencies.
Practical:
Analysis of single nucleotide polymorphisms (SNPs) by qPCR.
The practical sessions will involve the use of recombinant DNA technologies (restriction endonucleases, PCR, and electrophoretic DNA analyses) to identify and characterise selected SNPs within the human genome. Students will be expected to research the literature and design experimental regimes based on information relating to the methodology. Some method development will be required, and the students will be expected to have carried out DNA sequence analyses and literature search on the SNPs and DNA sequence before starting the practical work.
Tutorials
Two pastoral tutorials will be provided.
Module Overview:
This module aims to develop a reflective understanding of the genetic basis of disease and its investigation.
This module aims to develop a reflective understanding of the genetic basis of disease and its investigation.
Additional Information:This module aims to develop understanding of the contribution of chromosomes and genes to health and disease. A range of disorders will be covered with an introduction to relevant techniques and therapeutic approaches.