Teaching Responsibility
LJMU Schools involved in Delivery:
Pharmacy & Biomolecular Sciences
Learning Methods
Lecture
Tutorial
Workshop
Module Offerings
6004APCHEM-JAN-CTY
Aims
To convey some of the most important modern chemical transformations involved in pharmaceutical, agrichemical and materials science. This will equip the learner with the theoretical knowledge that will be applied in the industrial setting.
Learning Outcomes
1.
Devise successful routes to molecules requiring several synthetic steps.
2.
Employ frontier molecular orbital theory with respect to pericyclic reactions e.g. Diels-Alder.
3.
Predict how radicals and other reactive species can be used in synthesis and ionic rearrangements.
4.
Utilise transition metal-mediated chemistry to form C-C bonds.
Module Content
Outline Syllabus:The student will be introduced to contemporary methods for organic synthesis and will learn how to plan a successful synthetic route. Including, some useful oxidation methods, such as epoxidation and dihydroxylation. Frontier molecular orbital theory with respect to pericyclic reactions e.g. Diels-Alder, and the role of reactive intermediates in organic synthesis e.g. radicals, carbenes, nitrenes, ionic rearrangements. Transition metal mediated processes (stoichiometric and catalytic): 1) homogeneous hydrogenation and asymmetric catalysis; 2) catalytic and stoichiometric oxidation reactions; 3) organopalladium intermediates synthesis e.g. Suzuki, Sonagashira, Stille, Heck cross-coupling reactions.
Module Overview:
In this module you will be introduced to contemporary methods for organic synthesis and will learn how to plan a successful synthetic route. This includes useful oxidation methods such as epoxidation and dihydroxylation. Your study will be supported by workshops and problem-solving based exercise with peer-learning opportunity. This includes problems involving the correct assignment of structures, reagents, reaction conditions and mechanistic details.
In this module you will be introduced to contemporary methods for organic synthesis and will learn how to plan a successful synthetic route. This includes useful oxidation methods such as epoxidation and dihydroxylation. Your study will be supported by workshops and problem-solving based exercise with peer-learning opportunity. This includes problems involving the correct assignment of structures, reagents, reaction conditions and mechanistic details.
Additional Information:The module will cover up-to-date methods of bond synthesis, allowing access to important molecules in terms of the materials applications covered elsewhere. This will include considerable emphasis on transition metal-mediated processes. Learning outcomes will be supported by workshops, following a problem-solving based exercise with peer-learning opportunity. This will include problems involving the correct assignment of structures, reagents, reaction conditions and mechanistic details.