Teaching Responsibility
LJMU Schools involved in Delivery:
Pharmacy & Biomolecular Sciences
Learning Methods
Lecture
Practical
Seminar
Workshop
Module Offerings
5102BCBMOL-SEP-CTY
Aims
Gain a thorough understanding of how metabolic pathways are integrated and regulated in prokaryote and eukaryote cells. Consider and understand how pathways governing detoxification operate in eukaryote cells. Evaluate the use of laboratory test for the determination of biochemically important molecules.
Learning Outcomes
1.
Demonstrate an understanding of the mechanisms regulating biochemical pathways (biosynthetic and detoxification) operating in eukaryotic and prokaryotic cells.
2.
Appraise the role of biochemical tests in a clinical setting.
3.
Analyse and evaluate experimental findings by referring to the literature
Module Content
Outline Syllabus:Introduction to clinical Biochemistry.
Integration and control of metabolism.
Biosynthetic pathways including: amino acids, nucleotides, steroids, etc.
Calvin cycle and Pentose phosphate pathway.
Detoxification - P450 family, ROS, glutathione.
Techniques linked to clinical biochemistry analysis: LDH, using spectrophotometric enzyme assays to determine the activities of mitochondrial respiratory chain complex I, and the mitochondrial marker, citrate synthase.
Module Overview:
This module will enable you to gain a deeper understanding of the regulation and interaction of metabolic pathways within eukaryotic and prokaryotic cells. You will evaluate the use of laboratory tests for the determination of biochemically important molecules.
This module will enable you to gain a deeper understanding of the regulation and interaction of metabolic pathways within eukaryotic and prokaryotic cells. You will evaluate the use of laboratory tests for the determination of biochemically important molecules.
Additional Information:This module will enable students to gain a deeper understanding of the regulation and interaction of metabolic pathways within eukaryotic and prokaryotic cells. Detoxification within eukaryotic cells will be introduced. Recommended text and journal reference links can be found on the Canvas site for this module.
The practicals in this module provide the student with experience of the current biochemical assays employed to diagnose mitochondrial respiratory chain disorders in a NHS laboratory and are run and supervised by an honorary consultant clinical Scientist.
Assessments
Centralised Exam
Portfolio