Teaching Responsibility
LJMU Schools involved in Delivery:
Pharmacy & Biomolecular Sciences
Learning Methods
Lecture
Practical
Workshop
Module Offerings
4006PHASCI-JAN-CTY
Aims
To emphasise those chemical properties which are significant with respect to the involvement of drugs in biochemical transformations. To develop an ability to gather, evaluate and communicate scientific information. To facilitate the application of information presented in this module to the solution of problems.
Learning Outcomes
1.
Identify the essential similarities between chemical and biochemical transformations and demonstrate a basic knowledge of the properties of biologically significant molecules
2.
Demonstrate knowledge of functional groups as applied to biochemical molecules
3.
Describe the structure and function of proteins including the kinetics of enzyme action and types of enzyme inhibition
4.
Demonstrate a knowledge of the genetic basis of disease and the potential for gene therapy, including the processes involved in DNA replication and transcription
5.
Demonstrate an ability to gather, evaluate and communicate information relevant to the module and apply that information to the solution of problems
Module Content
Outline Syllabus:Biomolecules: review of functional groups with particular reference to biologically significant molecules; natural products; structure, synthesis and function of proteins and enzymes; nucleic acids; genes; antibodies; DNA; mRNA translation; micronutrients; vitamins
Biochemistry: the kinetics of enzyme action and types of enzyme inhibition; normal and abnormal metabolism with an overview of metabolic pathways and physiological use of energy sources; DNA replication and transcription.
Genetics: introduction; molecular genetics; genetic basis of disease and an introduction to the concept of gene therapy
Bioassays: protein concentration; enzyme activity
Practical: enzyme kinetics of PNP, presence/absence of inhibitor
Practical: protein bioassay, scenario-based
Module Overview:
The aim of this module is to develop your ability to gather, evaluate and communicate scientific information in order to facilitate the application of information presented to solve problems.
The aim of this module is to develop your ability to gather, evaluate and communicate scientific information in order to facilitate the application of information presented to solve problems.
Additional Information:Formative assessment in the form of an online quiz covering exam style MCQ questions
Practical sessions will involve students gaining experience of basic enzyme and protein bioassays; developing data analysis and reporting skills.
Exam will assess students understanding of biologically active molecules